This Knowledgebase article provides information about Trend Micro OfficeScan Corporate Edition specific advice.
Neverfail recommends the following when implementing Neverfail with Trend Anti-Virus products:
Neverfail works with Trend Micro's file level scanning software Trend Server Protect. This product can be used in conjunction with Trend's ScanMail for Exchange. Please ensure that the advice contained in Knowledgebase article #104 - 'Neverfail Heartbeat and Anti-Virus – General Advice Regarding Interoperability with Anti-Virus Scanners' is followed.
As Indicated Above